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Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice

Sepsis is characterized by systemic inflammation, edema formation and hypo-perfusion leading to organ dysfunction and ultimately death. Activation of the transient receptor potential vanilloid type 4 (TRPV4) channel is associated with edema formation and circulatory collapse. Here, we show that TRPV...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dalsgaard, Thomas, Sonkusare, Swapnil K., Teuscher, Cory, Poynter, Matthew E., Nelson, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031985/
https://ncbi.nlm.nih.gov/pubmed/27653046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33841
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