Elementary Ca(2+) Signals Through Endothelial TRPV4 Channels Regulate Vascular Function

Major features of the transcellular signaling mechanism responsible for endothelium-dependent regulation of vascular smooth muscle tone are unresolved. We identified local calcium (Ca(2+)) signals (“sparklets”) in the vascular endothelium of resistance arteries that represent Ca(2+) influx through s...

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Bibliographische Detailangaben
Hauptverfasser: Sonkusare, Swapnil K., Bonev, Adrian D., Ledoux, Jonathan, Liedtke, Wolfgang, Kotlikoff, Michael I., Heppner, Thomas J., Hill-Eubanks, David C., Nelson, Mark T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715993/
https://ncbi.nlm.nih.gov/pubmed/22556255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1216283
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