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Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance

Leishmania has a plastic genome, and drug pressure can select for gene copy number variation (CNV). CNVs can apply either to whole chromosomes, leading to aneuploidy, or to specific genomic regions. For the latter, the amplification of chromosomal regions occurs at the level of homologous direct or...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:F1000Res
Päätekijät: Laffitte, Marie-Claude N., Leprohon, Philippe, Papadopoulou, Barbara, Ouellette, Marc
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: F1000Research 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031125/
https://ncbi.nlm.nih.gov/pubmed/27703673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.9218.1
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