Intrachromosomal Amplification, Locus Deletion and Point Mutation in the Aquaglyceroporin AQP1 Gene in Antimony Resistant Leishmania (Viannia) guyanensis

BACKGROUND: Antimony resistance complicates the treatment of infections caused by the parasite Leishmania. METHODOLOGY/PRINCIPAL FINDINGS: Using next generation sequencing, we sequenced the genome of four independent Leishmania guyanensis antimony-resistant (SbR) mutants and found different chromoso...

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Vydáno v:PLoS Negl Trop Dis
Hlavní autoři: Monte-Neto, Rubens, Laffitte, Marie-Claude N., Leprohon, Philippe, Reis, Priscila, Frézard, Frédéric, Ouellette, Marc
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332685/
https://ncbi.nlm.nih.gov/pubmed/25679388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003476
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