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Mdm2 Phosphorylation Regulates its Stability and has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis
ATM phosphorylation of Mdm2-S394 is required for robust p53 stabilization and activation in DNA damaged cells. We have now utilized Mdm2(S394A) knock-in mice to determine that phosphorylation of Mdm2-S394 regulates p53 activity and the DNA damage response in lymphatic tissues in vivo by modulating M...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5031082/ https://ncbi.nlm.nih.gov/pubmed/27568562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.014 |
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