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Mdm2 Phosphorylation Regulates its Stability and has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis

ATM phosphorylation of Mdm2-S394 is required for robust p53 stabilization and activation in DNA damaged cells. We have now utilized Mdm2(S394A) knock-in mice to determine that phosphorylation of Mdm2-S394 regulates p53 activity and the DNA damage response in lymphatic tissues in vivo by modulating M...

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Udgivet i:Cell Rep
Main Authors: Carr, Michael I., Roderick, Justine E., Gannon, Hugh S., Kelliher, Michelle A., Jones, Stephen N.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031082/
https://ncbi.nlm.nih.gov/pubmed/27568562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.014
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