Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4

During homeostasis, hematopoietic stem cells (HSCs) are mostly kept in quiescence with only minor contribution to steady-state hematopoiesis. However, in stress situations such as infection, chemotherapy, or transplantation, HSCs are forced to proliferate and rapidly regenerate compromised hematopoi...

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Pubblicato in:J Exp Med
Autori principali: Uckelmann, Hannah, Blaszkiewicz, Sandra, Nicolae, Claudia, Haas, Simon, Schnell, Alexandra, Wurzer, Stephan, Wagener, Raimund, Aszodi, Attila, Essers, Marieke Alida Gertruda
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2016
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030798/
https://ncbi.nlm.nih.gov/pubmed/27573814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151713
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