RNA duplex map in living cells reveals higher order transcriptome structure

RNA has the intrinsic property to base pair, forming complex structures fundamental to its diverse functions. Here we develop PARIS, a method based on reversible psoralen-crosslinking for global mapping of RNA duplexes with near base-pair resolution in living cells. PARIS analysis in three human and...

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Publicado no:Cell
Main Authors: Lu, Zhipeng, Zhang, Qiangfeng Cliff, Lee, Byron, Flynn, Ryan A., Smith, Martin A., Robinson, James T., Davidovich, Chen, Gooding, Anne R., Goodrich, Karen J., Mattick, John S., Mesirov, Jill P., Cech, Thomas R., Chang, Howard Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029792/
https://ncbi.nlm.nih.gov/pubmed/27180905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.04.028
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