Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health

BMAL1 and RORα are major regulators of the circadian molecular oscillator. Since previous work in other cell types has shown cross talk between circadian rhythm genes and hypoxic signaling, we investigated the role of BMAL1 and RORα in controlling HIF-1-dependent transcriptional responses in NP cell...

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Foilsithe in:Oncotarget
Main Authors: Suyama, Kaori, Silagi, Elizabeth S., Choi, Hyowon, Sakabe, Kou, Mochida, Joji, Shapiro, Irving M., Risbud, Makarand V.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2016
Ábhair:
Research Paper: Pathology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029610/
https://ncbi.nlm.nih.gov/pubmed/27049729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8521
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