[(64)Cu]‐labelled trastuzumab: optimisation of labelling by DOTA and NODAGA conjugation and initial evaluation in mice

The human epidermal growth factor receptor‐2 (HER2) is overexpressed in 20–30% of all breast cancer cases, leading to increased cell proliferation, growth and migration. The monoclonal antibody, trastuzumab, binds to HER2 and is used for treatment of HER2‐positive breast cancer. Trastuzumab has prev...

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Detalles Bibliográficos
Publicado en:J Labelled Comp Radiopharm
Main Authors: Schjoeth‐Eskesen, Christina, Nielsen, Carsten Haagen, Heissel, Søren, Højrup, Peter, Hansen, Paul Robert, Gillings, Nic, Kjaer, Andreas
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2015
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029596/
https://ncbi.nlm.nih.gov/pubmed/25906708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.3287
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