[(64)Cu]‐labelled trastuzumab: optimisation of labelling by DOTA and NODAGA conjugation and initial evaluation in mice

The human epidermal growth factor receptor‐2 (HER2) is overexpressed in 20–30% of all breast cancer cases, leading to increased cell proliferation, growth and migration. The monoclonal antibody, trastuzumab, binds to HER2 and is used for treatment of HER2‐positive breast cancer. Trastuzumab has prev...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Labelled Comp Radiopharm
Auteurs principaux: Schjoeth‐Eskesen, Christina, Nielsen, Carsten Haagen, Heissel, Søren, Højrup, Peter, Hansen, Paul Robert, Gillings, Nic, Kjaer, Andreas
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2015
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029596/
https://ncbi.nlm.nih.gov/pubmed/25906708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.3287
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