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Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

Activation of protein kinase C by phorbol esters is known to accelerate the processing and secretion of the beta/A4 amyloid protein precursor. We have now examined various first messengers that increase protein kinase C activity of target cells for their ability to affect beta/A4 amyloid protein pre...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Buxbaum, J D, Oishi, M, Chen, H I, Pinkas-Kramarski, R, Jaffe, E A, Gandy, S E, Greengard, P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50280/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1359534/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.21.10075
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