Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

Activation of protein kinase C by phorbol esters is known to accelerate the processing and secretion of the beta/A4 amyloid protein precursor. We have now examined various first messengers that increase protein kinase C activity of target cells for their ability to affect beta/A4 amyloid protein pre...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Buxbaum, J D, Oishi, M, Chen, H I, Pinkas-Kramarski, R, Jaffe, E A, Gandy, S E, Greengard, P
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1992
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50280/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1359534/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.21.10075
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