Collagen degradation and MMP9 activation by Enterococcus faecalis contributes to intestinal anastomotic leak

Even under the most expert care, a properly constructed intestinal anastomosis can fail to heal resulting in leakage of its contents, peritonitis and sepsis. The cause of anastomotic leak remains unknown and its incidence has not changed in decades. Here, we demonstrate that the commensal bacterium...

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Udgivet i:Sci Transl Med
Main Authors: Shogan, B. D., Belogortseva, N., Luong, P. M., Zaborin, A., Lax, S., Bethel, Cindy, Ward, M., Muldoon, J. P., Singer, M., An, G., Umanskiy, K., Konda, V., Shakhsheer, B., Luo, J., Klabbers, R., Hancock, L. E., Gilbert, J., Zaborina, O., Alverdy, J. C.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027898/
https://ncbi.nlm.nih.gov/pubmed/25947163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010658
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