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Prediction of multidimensional drug dose responses based on measurements of drug pairs

Finding potent multidrug combinations against cancer and infections is a pressing therapeutic challenge; however, screening all combinations is difficult because the number of experiments grows exponentially with the number of drugs and doses. To address this, we present a mathematical model that pr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zimmer, Anat, Katzir, Itay, Dekel, Erez, Mayo, Avraham E., Alon, Uri
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027409/
https://ncbi.nlm.nih.gov/pubmed/27562164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606301113
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