A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve

Understanding the natural evolution and structural changes involved in broadly neutralizing antibody (bnAb) development holds great promise for improving the design of prophylactic influenza vaccines. Here we report an haemagglutinin (HA) stem-directed bnAb, 3I14, isolated from human memory B cells,...

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Vydáno v:Nat Commun
Hlavní autoři: Fu, Ying, Zhang, Zhen, Sheehan, Jared, Avnir, Yuval, Ridenour, Callie, Sachnik, Thomas, Sun, Jiusong, Hossain, M. Jaber, Chen, Li-Mei, Zhu, Quan, Donis, Ruben O., Marasco, Wayne A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027281/
https://ncbi.nlm.nih.gov/pubmed/27619409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12780
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