A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve

Understanding the natural evolution and structural changes involved in broadly neutralizing antibody (bnAb) development holds great promise for improving the design of prophylactic influenza vaccines. Here we report an haemagglutinin (HA) stem-directed bnAb, 3I14, isolated from human memory B cells,...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Fu, Ying, Zhang, Zhen, Sheehan, Jared, Avnir, Yuval, Ridenour, Callie, Sachnik, Thomas, Sun, Jiusong, Hossain, M. Jaber, Chen, Li-Mei, Zhu, Quan, Donis, Ruben O., Marasco, Wayne A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027281/
https://ncbi.nlm.nih.gov/pubmed/27619409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12780
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