Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies against Influenza A Viruses

Recent studies have shown high usage of the IGHV1-69 germline immunoglobulin gene for influenza hemagglutinin stem-directed broadly-neutralizing antibodies (HV1-69-sBnAbs). Here we show that a major structural solution for these HV1-69-sBnAbs is achieved through a critical triad comprising two CDR-H...

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Hauptverfasser: Avnir, Yuval, Tallarico, Aimee S., Zhu, Quan, Bennett, Andrew S., Connelly, Gene, Sheehan, Jared, Sui, Jianhua, Fahmy, Amr, Huang, Chiung-yu, Cadwell, Greg, Bankston, Laurie A., McGuire, Andrew T., Stamatatos, Leonidas, Wagner, Gerhard, Liddington, Robert C., Marasco, Wayne A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006906/
https://ncbi.nlm.nih.gov/pubmed/24788925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004103
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