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STING requires the adaptor TRIF to trigger innate immune responses to microbial infection
The intracellular microbial nucleic acid sensors, TLR3 and STING, recognize pathogen molecules and signal to activate the interferon pathway. The TIR-domain containing protein TRIF is the sole adaptor of TLR3. Here we report an essential role for TRIF in STING signaling: various activators of STING...
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| Publicat a: | Cell Host Microbe |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5026396/ https://ncbi.nlm.nih.gov/pubmed/27631700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2016.08.002 |
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