Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

The innate immune system senses infection by detecting evolutionarily conserved molecules essential for microbial survival or abnormal location of molecules. Here we demonstrate the existence of a novel innate detection mechanism, which is induced by fusion between viral envelopes and target cells....

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Main Authors: Holm, Christian K, Jensen, Søren B, Jakobsen, Martin R, Cheshenko, Natalia, Horan, Kristy A, Moeller, Hanne B, Gonzalez-Dosal, Regina, Rasmussen, Simon B, Christensen, Maria H., Yarovinsky, Timur O, Rixon, Frazer J, Herold, Betsy C, Fitzgerald, Katherine A, Paludan, Søren R
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411909/
https://ncbi.nlm.nih.gov/pubmed/22706339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2350
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