Suppression of systemic autoimmunity by the innate immune adaptor STING

Cytosolic DNA-sensing pathways that signal via Stimulator of interferon genes (STING) mediate immunity to pathogens and also promote autoimmune pathology in DNaseII- and DNaseIII-deficient mice. In contrast, we report here that STING potently suppresses inflammation in a model of systemic lupus eryt...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sharma, Shruti, Campbell, Allison M., Chan, Jennie, Schattgen, Stefan A., Orlowski, Gregory M., Nayar, Ribhu, Huyler, Annie H., Nündel, Kerstin, Mohan, Chandra, Berg, Leslie J., Shlomchik, Mark J., Marshak-Rothstein, Ann, Fitzgerald, Katherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343138/
https://ncbi.nlm.nih.gov/pubmed/25646421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420217112
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