STING requires the adaptor TRIF to trigger innate immune responses to microbial infection

The intracellular microbial nucleic acid sensors, TLR3 and STING, recognize pathogen molecules and signal to activate the interferon pathway. The TIR-domain containing protein TRIF is the sole adaptor of TLR3. Here we report an essential role for TRIF in STING signaling: various activators of STING...

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Pubblicato in:Cell Host Microbe
Autori principali: Wang, Xin, Majumdar, Tanmay, Kessler, Patricia, Ozhegov, Evgeny, Zhang, Ying, Chattopadhyay, Saurabh, Barik, Sailen, Sen, Ganes C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026396/
https://ncbi.nlm.nih.gov/pubmed/27631700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2016.08.002
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