Protein Folding Activity of the Ribosome is involved in Yeast Prion Propagation

6AP and GA are potent inhibitors of yeast and mammalian prions and also specific inhibitors of PFAR, the protein-folding activity borne by domain V of the large rRNA of the large subunit of the ribosome. We therefore explored the link between PFAR and yeast prion [PSI(+)] using both PFAR-enriched mu...

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Publicado en:Sci Rep
Main Authors: Blondel, Marc, Soubigou, Flavie, Evrard, Justine, Nguyen, Phu hai, Hasin, Naushaba, Chédin, Stéphane, Gillet, Reynald, Contesse, Marie-Astrid, Friocourt, Gaëlle, Stahl, Guillaume, Jones, Gary W., Voisset, Cécile
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025663/
https://ncbi.nlm.nih.gov/pubmed/27633137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32117
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