Precommitment low-level Neurog3 expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells

The current model for endocrine cell specification in the pancreas invokes high-level production of the transcription factor Neurogenin 3 (Neurog3) in Sox9(+) bipotent epithelial cells as the trigger for endocrine commitment, cell cycle exit, and rapid delamination toward proto-islet clusters. This...

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Detalles Bibliográficos
Publicado en:Genes Dev
Main Authors: Bechard, Matthew E., Bankaitis, Eric D., Hipkens, Susan B., Ustione, Alessandro, Piston, David W., Yang, Yu-Ping, Magnuson, Mark A., Wright, Christopher V.E.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024683/
https://ncbi.nlm.nih.gov/pubmed/27585590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.284729.116
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