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ROCK-nmMyoII, Notch and Neurog3 gene-dosage link epithelial morphogenesis with cell fate in the pancreatic endocrine-progenitor niche
During mouse pancreas organogenesis, endocrine cells are born from progenitors residing in an epithelial plexus niche. After a period in a lineage-primed Neurog3(LO) state, progenitors become endocrine committed via upregulation of Neurog3. We find that the Neurog3(LO) to Neurog3(HI) transition is a...
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| Publicado en: | Development |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Company of Biologists Ltd
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6176929/ https://ncbi.nlm.nih.gov/pubmed/30126902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.162115 |
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