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A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses

Cancer therapy targets malignant cells that are surrounded by a diverse complement of nonmalignant stromal cells. Therapy-induced damage of normal cells can alter the tumor microenvironment, causing cellular senescence and activating cancer-promoting inflammation. However, how these damage responses...

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Bibliografische gegevens
Gepubliceerd in:Genes Dev
Hoofdauteurs: Bent, Eric H., Gilbert, Luke A., Hemann, Michael T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024680/
https://ncbi.nlm.nih.gov/pubmed/27566778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.284851.116
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