Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology

Cardiopulmonary complications are the leading cause of mortality in sickle cell anemia (SCA). Elevated tricuspid regurgitant jet velocity, pulmonary hypertension, diastolic, and autonomic dysfunction have all been described, but a unifying pathophysiology and mechanism explaining the poor prognosis...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Bakeer, Nihal, James, Jeanne, Roy, Swarnava, Wansapura, Janaka, Shanmukhappa, Shiva Kumar, Lorenz, John N., Osinska, Hanna, Backer, Kurt, Huby, Anne-Cecile, Shrestha, Archana, Niss, Omar, Fleck, Robert, Quinn, Charles T., Taylor, Michael D., Purevjav, Enkhsaikhan, Aronow, Bruce J., Towbin, Jeffrey A., Malik, Punam
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024607/
https://ncbi.nlm.nih.gov/pubmed/27503873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600311113
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