Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology

Cardiopulmonary complications are the leading cause of mortality in sickle cell anemia (SCA). Elevated tricuspid regurgitant jet velocity, pulmonary hypertension, diastolic, and autonomic dysfunction have all been described, but a unifying pathophysiology and mechanism explaining the poor prognosis...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bakeer, Nihal, James, Jeanne, Roy, Swarnava, Wansapura, Janaka, Shanmukhappa, Shiva Kumar, Lorenz, John N., Osinska, Hanna, Backer, Kurt, Huby, Anne-Cecile, Shrestha, Archana, Niss, Omar, Fleck, Robert, Quinn, Charles T., Taylor, Michael D., Purevjav, Enkhsaikhan, Aronow, Bruce J., Towbin, Jeffrey A., Malik, Punam
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024607/
https://ncbi.nlm.nih.gov/pubmed/27503873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600311113
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