NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation

Activation of metabolic signalling by IL-15 is required for natural killer (NK) cell development. Here we show that Tsc1, a repressor of mTOR, is dispensable for the terminal maturation, survival and function of NK cells but is critical to restrict exhaustive proliferation of immature NK cells and a...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yang, Meixiang, Chen, Shasha, Du, Juan, He, Junming, Wang, Yuande, Li, Zehua, Liu, Guangao, Peng, Wanwen, Zeng, Xiaokang, Li, Dan, Xu, Panglian, Guo, Wei, Chang, Zai, Wang, Song, Tian, Zhigang, Dong, Zhongjun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023956/
https://ncbi.nlm.nih.gov/pubmed/27601261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12730
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