ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Mutations in Cu/Zn superoxide dismutase (SOD1) are responsible for approximately 20 % of the familial ALS cases. ALS-causing SOD1 mutants display a gain-of-toxicity phenotype, but the nature of this toxicity is still not fully...

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Dettagli Bibliografici
Pubblicato in:Acta Neuropathol
Autori principali: Gal, Jozsef, Kuang, Lisha, Barnett, Kelly R., Zhu, Brian Z., Shissler, Susannah C., Korotkov, Konstantin V., Hayward, Lawrence J., Kasarskis, Edward J., Zhu, Haining
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2016
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023729/
https://ncbi.nlm.nih.gov/pubmed/27481264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1601-x
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