HDAC6 Regulates Mutant SOD1 Aggregation through Two SMIR Motifs and Tubulin Acetylation

Histone deacetylase 6 (HDAC6) is a tubulin deacetylase that regulates protein aggregation and turnover. Mutations in Cu/Zn superoxide dismutase (SOD1) linked to familial amyotrophic lateral sclerosis (ALS) make the mutant protein prone to aggregation. However, the role of HDAC6 in mutant SOD1 aggreg...

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Hlavní autoři: Gal, Jozsef, Chen, Jing, Barnett, Kelly R., Yang, Liuqing, Brumley, Erin, Zhu, Haining
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663524/
https://ncbi.nlm.nih.gov/pubmed/23580651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.431957
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