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p62-enriched inclusion bodies in macrophages protect against atherosclerosis

Autophagy is a catabolic cellular mechanism that degrades dysfunctional proteins and organelles. Atherosclerotic plaque formation is enhanced in mice with macrophages that cannot undergo autophagy because of a deficiency of an autophagy component such as ATG5. We showed that exposure of macrophages...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Sergin, Ismail, Bhattacharya, Somashubhra, Emanuel, Roy, Esen, Emel, Stokes, Carl J., Evans, Trent D., Arif, Batool, Curci, John A., Razani, Babak
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023144/
https://ncbi.nlm.nih.gov/pubmed/26732762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad5614
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