Lipid Nanoparticle-mediated siRNA Transfer Against PCTAIRE1/PCTK1/Cdk16 Inhibits In Vivo Cancer Growth

PCTAIRE1/CDK16/PCTK1 plays critical roles in cancer cell proliferation and antiapoptosis. To advance our previously published in vitro results with PCTAIRE1 silencing, we examined the in vivo therapeutic potential of this approach by using small interfering RNA (siRNA) encapsulated by lipid nanopart...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Ther Nucleic Acids
Auteurs principaux: Yanagi, Teruki, Tachikawa, Kiyoshi, Wilkie-Grantham, Rachel, Hishiki, Asami, Nagai, Ko, Toyonaga, Ellen, Chivukula, Pad, Matsuzawa, Shu-ichi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5022131/
https://ncbi.nlm.nih.gov/pubmed/27351680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.40
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