Lipid Nanoparticle-mediated siRNA Transfer Against PCTAIRE1/PCTK1/Cdk16 Inhibits In Vivo Cancer Growth

PCTAIRE1/CDK16/PCTK1 plays critical roles in cancer cell proliferation and antiapoptosis. To advance our previously published in vitro results with PCTAIRE1 silencing, we examined the in vivo therapeutic potential of this approach by using small interfering RNA (siRNA) encapsulated by lipid nanopart...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Yanagi, Teruki, Tachikawa, Kiyoshi, Wilkie-Grantham, Rachel, Hishiki, Asami, Nagai, Ko, Toyonaga, Ellen, Chivukula, Pad, Matsuzawa, Shu-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5022131/
https://ncbi.nlm.nih.gov/pubmed/27351680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.40
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