Lipid Nanoparticle-mediated siRNA Transfer Against PCTAIRE1/PCTK1/Cdk16 Inhibits In Vivo Cancer Growth

PCTAIRE1/CDK16/PCTK1 plays critical roles in cancer cell proliferation and antiapoptosis. To advance our previously published in vitro results with PCTAIRE1 silencing, we examined the in vivo therapeutic potential of this approach by using small interfering RNA (siRNA) encapsulated by lipid nanopart...

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Dades bibliogràfiques
Publicat a:Mol Ther Nucleic Acids
Autors principals: Yanagi, Teruki, Tachikawa, Kiyoshi, Wilkie-Grantham, Rachel, Hishiki, Asami, Nagai, Ko, Toyonaga, Ellen, Chivukula, Pad, Matsuzawa, Shu-ichi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5022131/
https://ncbi.nlm.nih.gov/pubmed/27351680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.40
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