Pharmacokinetics and Pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in Mice and Non-human Primates

Locked nucleic acid (LNA) oligonucleotides have been successfully used to efficiently inhibit endogenous small noncoding RNAs in vitro and in vivo. We previously demonstrated that the direct miR-221 inhibition by the novel 13-mer LNA-i-miR-221 induces significant antimyeloma activity and upregulates...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther Nucleic Acids
Hauptverfasser: Gallo Cantafio, Maria Eugenia, Nielsen, Boye Schnack, Mignogna, Chiara, Arbitrio, Mariamena, Botta, Cirino, Frandsen, Niels M, Rolfo, Christian, Tagliaferri, Pierosandro, Tassone, Pierfrancesco, Di Martino, Maria Teresa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5022129/
https://ncbi.nlm.nih.gov/pubmed/27327137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.36
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