A Simple Method for TPMT and ITPA Genotyping Using Multiplex HRMA for Patients Treated with Thiopurine Drugs

Thiopurine methyltransferase (TPMT) and inosine triphosphatase (ITPA) are crucial enzymes involved in the metabolism of thiopurine drugs: azathioprine and 6-mercaptopurine, used in the treatment of leukemia or inflammatory bowel diseases (IBD). The activity in these enzymes correlates with the genet...

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Detalhes bibliográficos
Publicado no:Mol Diagn Ther
Main Authors: Skrzypczak-Zielinska, Marzena, Borun, Pawel, Bartkowiak-Kaczmarek, Anna, Zakerska-Banaszak, Oliwia, Walczak, Michal, Dobrowolska, Agnieszka, Kurzawski, Mateusz, Waszak, Malgorzata, Lipinski, Daniel, Plawski, Andrzej, Slomski, Ryszard
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2016
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021755/
https://ncbi.nlm.nih.gov/pubmed/27307154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40291-016-0217-0
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