The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy

OBJECTIVE: Leptin reverses hyperglycemia in rodent models of type 1 diabetes (T1D). Direct application of leptin to the brain can lower blood glucose in diabetic rodents, and can activate autonomic efferents and non-shivering thermogenesis in brown adipose tissue (BAT). We investigated whether lepti...

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Publicado en:Mol Metab
Autores principales: Denroche, Heather C., Kwon, Michelle M., Glavas, Maria M., Tudurí, Eva, Philippe, Marion, Quong, Whitney L., Kieffer, Timothy J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2016
Materias:
Brief Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021671/
https://ncbi.nlm.nih.gov/pubmed/27656409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.06.009
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