The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy

OBJECTIVE: Leptin reverses hyperglycemia in rodent models of type 1 diabetes (T1D). Direct application of leptin to the brain can lower blood glucose in diabetic rodents, and can activate autonomic efferents and non-shivering thermogenesis in brown adipose tissue (BAT). We investigated whether lepti...

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Bibliografski detalji
Izdano u:Mol Metab
Glavni autori: Denroche, Heather C., Kwon, Michelle M., Glavas, Maria M., Tudurí, Eva, Philippe, Marion, Quong, Whitney L., Kieffer, Timothy J.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2016
Teme:
Brief Communication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021671/
https://ncbi.nlm.nih.gov/pubmed/27656409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.06.009
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