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Impaired Ca(2+) Signaling in β-Cells Lacking Leptin Receptors by Cre-loxP Recombination
Obesity is a major risk factor for diabetes and is typically associated with hyperleptinemia and a state of leptin resistance. The impact of chronically elevated leptin levels on the function of insulin-secreting β-cells has not been elucidated. We previously generated mice lacking leptin signaling...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Public Library of Science
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3731269/ https://ncbi.nlm.nih.gov/pubmed/23936486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071075 |
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