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Impaired Ca(2+) Signaling in β-Cells Lacking Leptin Receptors by Cre-loxP Recombination

Obesity is a major risk factor for diabetes and is typically associated with hyperleptinemia and a state of leptin resistance. The impact of chronically elevated leptin levels on the function of insulin-secreting β-cells has not been elucidated. We previously generated mice lacking leptin signaling...

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Bibliografiska uppgifter
Huvudupphovsmän: Tudurí, Eva, Bruin, Jennifer E., Denroche, Heather C., Fox, Jessica K., Johnson, James D., Kieffer, Timothy J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731269/
https://ncbi.nlm.nih.gov/pubmed/23936486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071075
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