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Drugging Ras GTPase: A comprehensive mechanistic and signaling structural view
Ras proteins are small GTPases, cycling between inactive GDP-bound and active GTP-bound states. Through these switches they regulate signaling that controls cell growth and proliferation. Activating Ras mutations are associated with approximately 30% of human cancers, which are frequently resistant...
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| Publicado no: | Chem Soc Rev |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5021603/ https://ncbi.nlm.nih.gov/pubmed/27396271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cs00911a |
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