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Effect of biophysical properties of Phosphatidylserine (PS) particle on immune tolerance induction towards Factor VIII in a Hemophilia A mouse model

A major complication in the replacement therapy of Factor FVIII (FVIII) for Hemophilia A (HA) is the development of unwanted immune responses. Previous studies from our lab have shown that pretreatment of FVIII in the presence of Phosphatidylserine (PS) resulted in hyporesponsiveness to subsequent a...

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Bibliografische gegevens
Gepubliceerd in:J Pharm Sci
Hoofdauteurs: Ramakrishnan, Radha, Balu-Iyer, Sathy V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021571/
https://ncbi.nlm.nih.gov/pubmed/27431011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.06.008
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