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Exposure to Factor VIII Protein in the Presence of Phosphatidylserine Induces Hypo-responsiveness toward Factor VIII Challenge in Hemophilia A Mice

Administration of recombinant factor VIII (FVIII), an important co-factor in blood clotting cascade, elicits unwanted anti-FVIII antibodies in hemophilia A (HA) patients. Previously, FVIII associated with phosphatidylserine (PS) showed significant reduction in the anti-FVIII antibody response in HA...

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Autors principals: Gaitonde, Puneet, Ramakrishnan, Radha, Chin, Jamie, Kelleher, Raymond J., Bankert, Richard B., Balu-Iyer, Sathy V.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682509/
https://ncbi.nlm.nih.gov/pubmed/23649621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C112.396325
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