MAF1 suppresses AKT‐mTOR signaling and liver cancer through activation of PTEN transcription

The phosphatidylinositol 3‐kinase/phosphatidylinositol 3,4,5‐trisphosphate 3‐phosphatase/protein kinase B/mammalian target of rapamycin (PI3K‐PTEN‐AKT‐mTOR) pathway is a central controller of cell growth and a key driver for human cancer. MAF1 is an mTOR downstream effector and transcriptional repre...

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Publicado en:Hepatology
Autores principales: Li, Yue, Tsang, Chi Kwan, Wang, Suihai, Li, Xiao‐Xing, Yang, Yang, Fu, Liwu, Huang, Wenlin, Li, Ming, Wang, Hui‐Yun, Zheng, X.F. Steven
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Hepatobiliary Malignancies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021206/
https://ncbi.nlm.nih.gov/pubmed/26910647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28507
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