Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer

Tumor suppressor p53 preserves the genomic integrity by restricting anomaly at the gene level. The hotspots for mutation in half of all colon cancers reside in p53. Hence, in a p53-mutated cellular milieu targeting cancer cells may be achievable by targeting the paralogue(s) of p53. Here we have sho...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Ray, Pallab, Guha, Deblina, Chakraborty, Juni, Banerjee, Shuvomoy, Adhikary, Arghya, Chakraborty, Samik, Das, Tanya, Sa, Gaurisankar
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5020693/
https://ncbi.nlm.nih.gov/pubmed/27622714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32979
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