Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells

Deoxyinosine (dI) occurs in DNA either by oxidative deamination of a previously incorporated deoxyadenosine residue or by misincorporation of deoxyinosine triphosphate (dITP) from the nucleotide pool during replication. To exclude dITP from the pool, mammals possess specific hydrolysing enzymes, suc...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yoneshima, Yasuto, Abolhassani, Nona, Iyama, Teruaki, Sakumi, Kunihiko, Shiomi, Naoko, Mori, Masahiko, Shiomi, Tadahiro, Noda, Tetsuo, Tsuchimoto, Daisuke, Nakabeppu, Yusaku
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5020429/
https://ncbi.nlm.nih.gov/pubmed/27618981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32849
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