Polar Recognition Group Study of Keap1-Nrf2 Protein–Protein Interaction Inhibitors

[Image: see text] Directly disrupting the Keap1-Nrf2 protein–protein interaction (PPI) has emerged as an attractive way to activate Nrf2, and Keap1-Nrf2 PPI inhibitors have been proposed as potential agents to relieve inflammatory and oxidative stress diseases. In this work, we investigated the diac...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Lu, Meng-Chen, Tan, Shi-Jie, Ji, Jian-Ai, Chen, Zhi-Yun, Yuan, Zhen-Wei, You, Qi-Dong, Jiang, Zheng-Yu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2016
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018864/
https://ncbi.nlm.nih.gov/pubmed/27660687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00407
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