CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

The Keap1-Nrf2-ARE pathway regulates the constitutive and inducible transcription of various genes that encode detoxification enzymes, antioxidant proteins and anti-inflammatory proteins and has pivotal roles in the defence against cellular oxidative stress. In this study, we investigated the therap...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Redox Biol
Prif Awduron: Lu, Meng-Chen, Zhao, Jing, Liu, Yu-Ting, Liu, Tian, Tao, Meng-Min, You, Qi-Dong, Jiang, Zheng-Yu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2019
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614503/
https://ncbi.nlm.nih.gov/pubmed/31279986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101266
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