Changes in active site histidine hydrogen bonding trigger cryptochrome activation

Cryptochrome (CRY) is the principal light sensor of the insect circadian clock. Photoreduction of the Drosophila CRY (dCRY) flavin cofactor to the anionic semiquinone (ASQ) restructures a C-terminal tail helix (CTT) that otherwise inhibits interactions with targets that include the clock protein Tim...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Ganguly, Abir, Manahan, Craig C., Top, Deniz, Yee, Estella F., Lin, Changfan, Young, Michael W., Thiel, Walter, Crane, Brian R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018803/
https://ncbi.nlm.nih.gov/pubmed/27551082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606610113
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