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A glutamine amide flip elicits long distance allosteric responses in the LOV protein Vivid

Light-oxygen-voltage (LOV) domains sense blue light through the photochemical formation of a cysteinyl-flavin covalent adduct. Concurrent protonation at the flavin N5 position alters the hydrogen bonding interactions of an invariant Gln residue that has been proposed to flip its amide side chain as...

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Foilsithe in:J Am Chem Soc
Main Authors: Ganguly, Abir, Thiel, Walter, Crane, Brian R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5902025/
https://ncbi.nlm.nih.gov/pubmed/28145707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b10701
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