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Tuning flavin environment to detect and control light-induced conformational switching in Drosophila cryptochrome
Light-induction of an anionic semiquinone (SQ) flavin radical in Drosophila cryptochrome (dCRY) alters the dCRY conformation to promote binding and degradation of the circadian clock protein Timeless (TIM). Specific peptide ligation with sortase A attaches a nitroxide spin-probe to the dCRY C-termin...
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| Veröffentlicht in: | Commun Biol |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7910608/ https://ncbi.nlm.nih.gov/pubmed/33637846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01766-2 |
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